Comparison between the Diagnostic Yield of Cryobiopsy and Forceps Biopsy during Thoracoscopy

Comparison between the Diagnostic Yield of Cryobiopsy and Forceps Biopsy during Thoracoscopy

Atefeh Abedini1(MD); Fatemeh Razavi1(PhD student); Yazdan Jafari1(MD); Mihan Pourabdollah Toutkaboni2(MD); Habib Emami3(PhD); Negar Bandegani1(MD); Arda Kiani4*(MD)

۱Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

۲Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

۳Prevention and Control Research center, National Research Institute of Tuberculosis and Lung Diseases, Shahid beheshti University of Medical Sciences, Tehran, Iran

۴Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract:

Background and Objectives: Since there is an ongoing debate on choosing the most diagnostic method for parietal pleural biopsy obtaining, this study aimed to prospectively compare the safety, diagnostic yield as well as size of samples harvested using two techniques of cryobiopsy over conventional forceps biopsy in patients with pleural diseases.

Materials and Methods: Frothy cases suffering pleural effusion that were indicated for thoracoscopy studied. One to three samples were taken using cryobiopsy and three to five specimens were obtained through forceps biopsy in each case.

Findings: The median size of biopsies was 1.80 (ranged from 0.06 to 40.00 cu mm) using Cryobiopsy and 2.20 (ranged from 0.06 to 10.50 cu mm) using forceps biopsies which was not statistically significant (p=0.33). That is while the number of sampling was significantly lower in Cryobiopsy in comparison with forceps biopsies (1.5±۰٫۷۴ vs 3.7±۰٫۸۲, p= 0.000). The total complications were scarce using Cryobiopsy either Forceps Biopsy.

Conclusion: From the research that has been carried out, it is possible to conclude that not only the Cryobiopsy has an equal diagnostic yield with conventional Forceps Biopsy for detecting pleural malignancy as well as other pleural involvement but also in some cases has a higher diagnostic yield. However, the complications caused by Cryobiopsy were comparable or even less than of Forceps Biopsy.

Key Words: Thoracoscopy (D013906), Cryobiopsy, Rigid Forceps Biopsy, Pleural Effusion.